Complicações pulmonares após cirurgia de revascularização do miocárdio: fatores associados
Pulmonary complications after coronary artery bypass surgery: factors associated factors
Katerine Cristhine Cani, Kelly Cattelan Bonorino, Aline Almeida Gulart, Marina Palú, Manuela Karloh, Anamaria Fleig Mayer
Resumo
Introdução: A cirurgia de revascularização do miocárdio (CRM) está associada a efeitos deletérios sobre a função pulmonar. Esses efeitos podem estar relacionados ao tipo de cirurgia, tempo de internação e à presença de comorbidades, que contribuem para o risco de complicações pulmonares pós-operatórias (CPPO). Objetivo: Investigar quais fatores estão associados às CPPO em pacientes submetidos à CRM. Métodos: Trata-se de um estudo prospectivo observacional. Participaram do estudo 48 pacientes submetidos à CRM, divididos em: grupo complicações pulmonares e grupo sem complicações pulmonares. Os dados foram coletados mediante entrevista e levantamento de dados dos prontuários. Na análise estatística, a normalidade das variáveis foi verificada com o Teste de Shapiro-Wilk; o Teste exato de Fisher, para analisar a existência ou não de associação entre as CPPO e a presença de fatores relacionados; para comparação entre os grupos, utilizou-se o Teste U de Mann Whitney. Resultados: A amostra era predominantemente do sexo masculino (72,9%), com média de idade de 59,9±11,1 anos. As CPPO foram identificadas em 64,6% dos pacientes, sendo a maioria de Grau 1 (61,3%). A presença de doença pulmonar obstrutiva crônica foi o único fator que apresentou associação com as CPPO. O tempo de internação hospitalar/UTI foi maior no grupo complicações pulmonares (p<0,05). Conclusão: A doença pulmonar obstrutiva crônica foi o único fator que apresentou associação com as complicações pulmonares em pacientes submetidos à cirurgia de revascularização do miocárdio. Em adição, o tempo de internação hospitalar, nos pacientes que apresentaram complicações pulmonares, foi maior, em comparação aos pacientes que não apresentaram.
Palavras-chave
Abstract
Background: Cardiac surgery for coronary artery bypass grafting (CABG) is associated with deleterious effects on lung function. These effects may be related to factors inherent to surgery, the hospital stay and the presence of comorbidities that contribute to the risk of postoperative pulmonary complications (PPC). Objective: To investigate what factors are associated with PPC in patients undergoing CABG. Methods: This is a prospective and observational cohort study. Forty-eight patients undergoing CABG participated in the study and were separated into two groups: group with postoperative pulmonary complications and group without postoperative pulmonary complications. Data was collected via interviews and investigation of patients’ medical records. In the statistical analysis, the normality of the variables was assessed using the Shapiro-Wilk test; Fisher’s exact test was used to analyze the existence of associations between the presence of PPC and related factors; between groups comparisons were done using the Mann Whitney U test. Results: The sample was predominantly composed of men (72.9%) with mean age of 59.9 ± 11.1 years. PPC was identified in 64.6% of patients, most of whom classified as grade 1 (61.3%). The presence of chronic obstructive pulmonary disease was the only factor that was associated with PPC. The hospital / ICU stay was longer in the postoperative pulmonary complications group (p <0.05). Conclusion: Chronic obstructive pulmonary disease was the only factor that was associated with postoperative pulmonary complications in patients undergoing CABG. Length of hospital stay in patients with pulmonary complications was longer compared to patients without complications.
Keywords
References
1. Wijns W, Kolh P, Danchin N, Di Mario C, Falk V, Folliguet T, et al. Guidelines on myocardial revascularization. Rev Port Cardiol. 2011;30(12):951.
2. Wynne R, Botti M. Postoperative pulmonary dysfunction in adults after cardiac surgery with cardiopulmonary bypass: clinical significance and implications for practice. Am J Crit Care. 2004 Sep;13(5):384-93.
3. Hulzebos EH, Helders PJ, Favié NJ, De Bie RA, Brutel de la Riviere A, Van Meeteren NL. Preoperative intensive inspiratory muscle training to prevent postoperative pulmonary complications in high-risk patients undergoing CABG surgery: a randomized clinical trial. Jama. 2006 Oct 18;296(15):1851-7.
4. Al-Sarraf N, Raza A, Rowley S, Hughes A, Tolan M, Young V, et al. Short-term and long-term outcome in low body mass index patients undergoing cardiac surgery. Gen Thorac Cardiovasc Surg. 2009 Feb;57(2):87-93.
5. Weissman C. Pulmonary complications after cardiac surgery. Semin Cardiothorac Vasc Anesth. 2004 Sep;8(3):185-211.
6. García-Delgado M, Navarrete-Sánchez I, Colmenero M. Preventing and managing perioperative pulmonary complications following cardiac surgery. Curr Opin Anaesthesiol. 2014 Apr;27(2):146-52.
7. Jensen L, Yang L. Risk factors for postoperative pulmonary complications in coronary artery bypass graft surgery patients. Eur J Cardiovasc Nurs. 2007 Sep;6(3):241-6.
8. Ambrozin ARP, Cataneo AJM. Pulmonary function aspects after myocardial revascularization related to preoperative risk. Braz J Cardiovasc Surg. 2005 Oct-Dec;20(4):408-15.
9. Yánez-Brage I, Pita-Fernández S, Juffé-Stein A, Martínez-González U, Pértega-Díaz S, MauleónGarcía A. Respiratory physiotherapy and incidence of pulmonary complications in off-pump coronary artery bypass graft surgery: an observational follow-up study. BMC Pulm Med. 2009 Jul 28;9:36.
10. Ji Q, Mei Y, Wang X, Feng J, Cai J, Ding W. Risk factors for pulmonary complications following cardiac surgery with cardiopulmonary bypass. Int J Med Sci. 2013 Sep 10;10(11):1578-83.
11. Gimenes C, Barrile SR, Martinelli B, Ronchi CF, Arca EA, Gimenes R, et al. Association of pre and intraoperative variables with postoperative complications in coronary artery bypass graft surgery. Rev Bras Cir Cardiovasc. 2013 Oct-Dec;28(4):518-23.
12. Ortiz LD, Schaan CW, Leguisamo CP, Tremarin K, Mattos WL, Kalil RA, et al. Incidence of pulmonary complications in myocardial revascularization. Arq Bras Cardiol. 2010 Oct;95(4):441-6.
13. Soares GMT, Ferreira DCS, Gonçalves MPC, Alves TGS, David FL, Henriques KMC, et al. Prevalence of Major Postoperative Complicationsin Cardiac Surgery. Rev Bras Cardiol. 2011;24(3):139-46.
14. Ji Q, Zhao H, Mei Y, Shi Y, Ma R, Ding W. Impact of smoking on early clinical outcomes in patients undergoing coronary artery bypass grafting surgery. J Cardiothorac Surg. 2015 Feb 6;10:16.
15. Benedetto U, Albanese A, Kattach H, Ruggiero D, De Robertis F, Amrani M, et al. Smoking cessation before coronary artery bypass grafting improves operative outcomes. J Thorac Cardiovasc Surg. 2014 Aug;148(2):468-74.
16. Pauli JR, Cintra DE, Souza CT, Ropelle ER. New mechanisms by which physical exercise improves insulin resistance in the skeletal muscle. Arq Bras Endocrinol Metabol. 2009 Jun;53(4):399-408.
17. Ardeshiri M, Faritus Z, Ojaghi-Haghighi Z, Bakhshandeh H, Kargar F, Aghili R. Impact of metabolic syndrome on mortality and morbidity after coronary artery bypass grafting surgery. Res Cardiovasc med. 2014 Aug;3(3):e20270.
18. Ried M, Unger P, Puehler T, Haneya A, Schmid C, Diez C. Mild-to-moderate COPD as a risk factor for increased 30-day mortality in cardiac surgery. Thorac Cardiovasc Surg. 2010 Oct;58(7):387-91.
19. Laizo A, Delgado FE, Rocha GM. Complications that increase the time of Hospitalization at ICU of patients submitted to cardiac surgery. Rev Bras Cir Cardiovasc. 2010 Apr-Jun;25(2):166-71.
20. McKeon NJ, Timmins SN, Stewart H, Yerkovich ST, McKeon JL. Diagnosis of COPD before cardiac surgery. Eur Respir J. 2015 Nov;46(5):1498-500.
21. Global Initiative for Chronic Obstructive Lung Disease (GOLD). Global Strategy for Diagnosis, Management, and Prevention of COPD [Internet, cited 2016 Mar 28]. Avaiable from: http://www.goldcopd.org/
22. Agusti AG, Noguera A, Sauleda J, Sala E, Pons J, Busquets X. Systemic effects of chronic obstructive pulmonary disease. Eur Respir J. 2003 Feb;21(2):347-60.
23. Asimakopoulos G, Smith PL, Ratnatunga CP, Taylor KM. Lung injury and acute respiratory distress syndrome after cardiopulmonary bypass. Ann Thorac Surg. 1999 Sep;68(3):1107-15.
24. de Prost N, El-Karak C, Avila M, Ichinose F, Vidal Melo MF. Changes in cysteinyl leukotrienes during and after cardiac surgery with cardiopulmonary bypass in patients with and without chronic obstructive pulmonary disease. J Thorac Cardiovasc Surg. 2011 Jun;141(6):1496-502 e3.
25. Titinger DP, Lisboa LA, Matrangolo BL, Dallan LR, Dallan LA, Trindade EM, et al. Cardiac surgery costs according to the preoperative risk in the Brazilian public health system. Arq Bras Cardiol. 2015 Aug;105(2):130-8.